Mammalian Toxicity

RDDT Laboratories offers the following range of mammalian toxicology services:

• Acute toxicity studies:
  • Single and repeat dose studies up to 14 days duration according to OECD Test Guidelines or custom study design
  • Custom design for dose range finding and maximum tolerated dose studies
  • Dermal toxicity
  • Skin irritation/corrosion test in rabbits
  • Local lymph node skin sensitisation test in mice
• 28 day and 13 week repeat dose toxicity studies
  • Repeat dose studies according to OECD Test Guidelines
• Chronic toxicity studies
  • 6, 9 or 12 month duration
• Toxicokinetic studies
• Skin sensitisation and skin irritation studies
• Supporting services
  • Clinical pathology including in-house haematology, clinical biochemistry, histopathology analyses
  • Bioanalytical support for toxicokinetic studies
  • Consulting Services

Administration routes available include:

• Oral
• Subcutaneous
• Intravenous injection
• Interperitoneal
• Percutaneous
• Dermal
• Vaginal
• Rectal
• Urinary Bladder

The above studies can be performed in a range of species. RDDT Laboratories has exceptional expertise in rodent toxicology studies. Guinea pig and rabbit studies are also performed in-house. Dog and non-human primate studies are performed with RDDT Laboratories' GLP compliant partners.

Services are performed in compliance with regulatory authority test guidelines and are fully GLP compliant.

Non-GLP services are also available on request.