Clients may have a need for studies that are not part of the standard packages offered by RDDT Laboratories. These requests may be for efficacy assays or experiments which a client requires to be conducted in quality controlled laboratory conditions. RDDT Laboratories staff will be happy to discuss the requirements and design of these studies.

RDDT Laboratories is privileged to be a part of RMIT University with its broad range of capabilities, and is supported by the RMIT Consultants Group. RDDT Laboratories has also formed relationships with a number of quality service providers to extend its "in house" capabilities and maintains a register of approved contractors. These contractors must comply with either the ISO 17025 and/or OECD GLP guidelines.

Partnering with an established New Zealand company - Trinity Bioactives Ltd, RDDT Laboratories is now able to offer a wide collection of custom efficacy models which can be validated and performed to meet your needs. With over 20 custom efficacy models available both in vivo and in vitro this is a giant step forward for companies looking to demonstrate the pharmacological activity of their product in animal models prior to human studies.

RDDT Laboratories can offer the following range of disease models including:

ConditionIn vitroIn vivo
Angiogenesis
  1. Rat aortic ring
  2. Human umbilical venule/arteriole
  3. Macula/retina
  4. Sclera
  5. Choroid
  6. HUVEC
  7. BAEC
  1. Rat mesenteric window
Obesity
  1. Primary adipocytes
  2. Primary hepatocytes
  3. Hormones, modulators
  1. Zucker obese rat
  2. High fat diet (mouse & rat)
  3. Metabolic syndrome rodent models
Anti-inflammation
  1. Neutrophils
  2. Primary monocytes
  3. Primary macrophages
  
Diabetes
  1. Culture of pancreatic islets
  2. Glucose uptake by skeletal muscle
  3. Glucose uptake by adipocytes
  4. Glucose uptake by hepatocytes
  1. ZDF Rats
  2. Streptozotocin rats
Cancer
  1. Melanoma (mouse & human)
  2. Colon
  3. Brain
  4. Lung
  5. Breast
  6. Prostate
  7. Phaechromocytoma
  8. Basal cell carcinoma
  9. Squamous cell carcinoma
  1. Melanoma (mouse & human)
  2. Colon
  3. Brain
  4. Lung
  5. Breast
  6. Prostate
  7. Phaechromocytoma
  8. Basal cell carcinoma
  9. Squamous cell carcinoma
  10. Chemical induced colon (rat)
Thrombosis
  1. Thrombolysis
  2. Clotting
  1. Platelet function
Joint Conditions
  1. Chondrocyte cultures
  2. Synoviocyte cultures
  1. Acute joint inflammation
  2. Rheumatoid arthritis
  3. Osteoarthritis
Liver Function
  1. Hepatocyte cultures
  2. Liver metabolism
  1. Liver function
  2. Fibrosis & Sclerosis
  3. Liver metabolism
  4. Toxicology
Hypertension
  1. ANG Receptors
  2. ACE Inhibition
  1. SHR Rats
Extracellular matrix
  1. Collagen genetic variants
  2. Collagen synthesis
  1. Fibrosis models
  2. Extracellular matrix
  3. Collagen composition and metabolism
  4. Elastin composition and metabolism
  5. Glycosaminoglycan, proteoglycan composition and metabolism
Oxidative stress
  1. Total anti-oxidative capacity
  2. Measurement of reactive oxygen
  3. Assay of oxidative metabolism
  4. Lipid oxidation
  5. Protein oxidation
  6. Oxidation enzymes
  7. Anti-oxidative effects
  1. Total anti-oxidative capacity (serum)
  2. Measurement of reactive oxygen
  3. Assay of oxidative metabolism
  4. Lipid oxidation
  5. Protein oxidation
  6. Oxidation enzymes
Amino Acid Analysis
  1. Protein analysis
  2. Collagen and elastin analyses
  3. Serum amino acids
  
Dermatology
  1. Skin fibroblast cultures
  2. Skin keratinocyte cultures
  3. Metabolism of skin cells
  4. Stressed skin cells (eg UV radiation , oxidation)
  5. Mast cells
  6. Skin transport
  7. Skin absorption
  8. Metabolism of skin tissue
  9. Stressed skin tissue (eg UV radiation , oxidation)
  10. Skin inflammation
  11. Skin allergic reaction
  12. Atopic dermatitis
  13. Skin tanning
  14. Skin whitening
  
Allergy
  1. Mast cell cultures
  2. Histamine production
  
Immune reactivity
  1. T cell proliferation
  2. T cell metabolism
  3. NK cells
  4. T reg cells
  5. B cells
  1. Spleen immune cells
  2. Peyers patches cells
  3. Immunoglobulins
Ocular Conditions
  1. Macula angiogenesis
  2. Retinal angiogenesis
  3. Choroid angiogenesis
  4. Sclera angiogenesis
  
Gastroenterology
  1. Gut transport
  2. Smooth muscle contraction/relaxation
  1. Inflammatory bowel disease
  2. Bioavailability
Cardiovascular  
  1. Serum lipids
  2. High-Cholesterol diets
  3. Metabolic Syndrome models
Alzheimers disease
  1. Apoptosis
  2. Amyloid plaques
  3. PC-12 cells
  4. Foetal hippocampus cultures
  
Wound healing
  1. Fibroblast wounds
  2. Angiogenesis
  1. Excisional wounds (Healthy rats)
  2. Excisional wounds (Diabetic rats)
  3. Delayed wound healing
  4. Flaps
  5. 'Scaffolds' for wounds
Foetal development  
  1. Mating
  2. Conception
  3. Pregnancy and gestation
  4. Delivery
  5. Anatomy
Microbial Assays
  1. Bacterial cultures
  2. Viral cultures
  3. Fungal cultures
  4. Anti-infectives
  5. Antiseptics
  
Safety & Toxicity
  1. Cytotoxicity
  1. Sub-chronic
  2. Chronic
  3. Acute
  4. Specific systems (eg. neuro, renal, etc.)
  5. Reproductive